In Ghana, violence against women and girls is widespread. Recent estimates indicate that 28% of women report at least one form of violence in the past year and 45% report experiencing violence at some point in their lifetime. COMBAT (Community Based Action Teams) is a rural response strategy that aims to (i) reduce the incidence of VAWG in rural communities in Ghana, (ii) protect women’s rights via state and community structures; and, (iii) raise public awareness about the causes and consequences of VAWG. This evidence suggests that community-led evidence-based interventions supported by local actors (e.g. traditional and religious leaders) are uniquely placed to support prevention of, and response to, VAWG in this context.