The What Works to Prevent Violence Against Women and Girls Global Programme has carried out research to better understand how to prevent violence against women and girls living with disabilities, who are at an increased risk of violence, abuse, neglect, maltreatment and exploitation. Women and girls with disabilities also face additional pressures because they are regarded as unable to meet the social roles and expectations on women and girls to attract men, marry, bear children, or care for families. This can result in further social exclusion, which may contribute to development of depression or other mental illness, in addition to increasing their physical and economic vulnerabilities. While the evidence base is limited, this evidence brief identifies promising strategies to prevent violence against women girls with disabilities.